TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence. [electronic resource]
Producer: 20120409Description: 290-300 p. digitalISSN:- 1557-3265
- Aging -- genetics
- Animals
- Apoptosis -- genetics
- Blotting, Western
- Carcinoma, Squamous Cell -- genetics
- Fluorescent Antibody Technique
- Head and Neck Neoplasms -- genetics
- Humans
- Immunoenzyme Techniques
- Mice
- Mutation -- genetics
- Neoplasm Recurrence, Local -- diagnosis
- Radiation Tolerance -- genetics
- Reactive Oxygen Species -- metabolism
- Survival Rate
- Treatment Failure
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53 -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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