Concurrent HDAC and mTORC1 inhibition attenuate androgen receptor and hypoxia signaling associated with alterations in microRNA expression. [electronic resource]
Producer: 20120518Description: e27178 p. digitalISSN:- 1932-6203
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Drug Synergism
- Everolimus
- Genes, myc
- Histone Deacetylase Inhibitors -- pharmacology
- Hydroxamic Acids -- pharmacology
- Hypoxia -- metabolism
- Indoles
- Male
- Mice
- Mice, Transgenic
- MicroRNAs -- genetics
- Panobinostat
- Prostatic Neoplasms -- drug therapy
- Receptors, Androgen -- metabolism
- Signal Transduction -- drug effects
- Sirolimus -- analogs & derivatives
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Treatment Outcome
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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