PPARδ coordinates angiotensin II-induced senescence in vascular smooth muscle cells through PTEN-mediated inhibition of superoxide generation. [electronic resource]
Producer: 20120227Description: 44585-93 p. digitalISSN:- 1083-351X
- Amino Acid Substitution
- Angiotensin II -- genetics
- Animals
- Aorta -- cytology
- Cells, Cultured
- Cellular Senescence -- physiology
- Gene Knockdown Techniques
- Humans
- Mice
- Mice, Mutant Strains
- Muscle, Smooth, Vascular -- cytology
- Mutation, Missense
- Myocytes, Smooth Muscle -- cytology
- PTEN Phosphohydrolase -- genetics
- Phosphatidylinositol 3-Kinases -- genetics
- Proto-Oncogene Proteins c-akt -- physiology
- Receptors, Cytoplasmic and Nuclear -- genetics
- Signal Transduction -- physiology
- Superoxides -- metabolism
- Tumor Suppressor Protein p53 -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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