The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognize intact DNA. [electronic resource]
Producer: 19910123Description: 21907-13 p. digitalISSN:- 0021-9258
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- Cysteine -- physiology
- DNA -- metabolism
- DNA Damage
- DNA Mutational Analysis
- DNA Repair
- DNA-Binding Proteins -- genetics
- Enzyme Activation
- Humans
- Molecular Sequence Data
- Poly(ADP-ribose) Polymerases -- genetics
- Structure-Activity Relationship
- Substrate Specificity
- Zinc Fingers
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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