α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases. [electronic resource]
Producer: 20120224Description: 440-52 p. digitalISSN:- 1471-4159
- Aged
- Aged, 80 and over
- Alkaline Phosphatase -- genetics
- Analysis of Variance
- Animals
- Biophysics
- Calcineurin -- metabolism
- Calcium -- metabolism
- Cell Line, Tumor
- Conditioning, Psychological -- drug effects
- Disease Models, Animal
- Drug Administration Routes
- Electric Stimulation
- Fear -- drug effects
- Female
- Hippocampus -- cytology
- Humans
- In Vitro Techniques
- L-Lactate Dehydrogenase -- metabolism
- Long-Term Potentiation -- drug effects
- Male
- Memory Disorders -- chemically induced
- Mice
- Mice, Inbred C57BL
- Neuroblastoma -- pathology
- Neurodegenerative Diseases -- metabolism
- Neurons -- drug effects
- Patch-Clamp Techniques
- Rats
- Rats, Sprague-Dawley
- Transfection
- alpha-Synuclein -- chemistry
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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