The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes. [electronic resource]
Producer: 20120223Description: 251-61 p. digitalISSN:- 1528-0020
- Animals
- Bleeding Time
- Blood Platelets -- metabolism
- Blotting, Western
- Calcium -- metabolism
- Calcium Channels -- genetics
- Calcium Signaling
- Cells, Cultured
- Female
- Flow Cytometry
- Fluorescent Antibody Technique
- Humans
- Immediate-Early Proteins -- physiology
- Immunoenzyme Techniques
- Leukemia, Megakaryoblastic, Acute -- metabolism
- Male
- Megakaryocytes -- cytology
- Mice
- Mice, Knockout
- NF-kappa B -- genetics
- ORAI1 Protein
- Phosphorylation
- Platelet Aggregation
- Protein Serine-Threonine Kinases -- physiology
- RNA, Messenger -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Thrombosis -- etiology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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