SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation. [electronic resource]
Producer: 20120315Description: 283-92 p. digitalISSN:- 1759-4685
- Animals
- Cysteine Endopeptidases -- genetics
- Endopeptidases -- genetics
- HEK293 Cells
- Humans
- Immunity, Innate -- immunology
- Interferon Regulatory Factor-3 -- genetics
- Interferon-beta -- metabolism
- Mice
- Mice, Knockout
- Multienzyme Complexes -- genetics
- RNA Interference
- Sendai virus -- immunology
- Signal Transduction -- immunology
- Small Ubiquitin-Related Modifier Proteins -- metabolism
- Sumoylation
- Ubiquitination
- Virus Replication
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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