Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays. [electronic resource]
Producer: 20120611Description: 7614-24 p. digitalISSN:- 1557-3265
- Animals
- Aurora Kinase A
- Aurora Kinases
- Azepines -- chemistry
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Dideoxynucleosides -- pharmacokinetics
- Female
- Fluorine Radioisotopes
- HCT116 Cells
- HeLa Cells
- Humans
- Lymphoma -- drug therapy
- Mice
- Mice, Nude
- Mice, SCID
- Mitotic Index
- Molecular Structure
- Neoplasms -- drug therapy
- Phosphorylation -- drug effects
- Positron-Emission Tomography
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Pyrimidines -- chemistry
- Spindle Apparatus -- drug effects
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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