E2FBP1 antagonizes the p16(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability. [electronic resource]
Producer: 20111101Description: 200-8 p. digitalISSN:- 1674-2818
- Cell Line, Tumor
- Cells, Cultured
- Cellular Senescence -- genetics
- Cyclin-Dependent Kinase Inhibitor p16 -- antagonists & inhibitors
- DNA-Binding Proteins -- deficiency
- Down-Regulation
- Fibroblasts
- Gene Expression Regulation
- Humans
- Intranuclear Inclusion Bodies -- metabolism
- MAP Kinase Signaling System
- Nuclear Proteins -- genetics
- Promyelocytic Leukemia Protein
- Protein Isoforms
- Protein Stability
- RNA Interference
- Retinoblastoma Protein -- antagonists & inhibitors
- Transcription Factors -- deficiency
- Transfection
- Tumor Suppressor Protein p53 -- physiology
- Tumor Suppressor Proteins -- genetics
- Ubiquitination
- ras Proteins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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