Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in mice. [electronic resource]
Producer: 20120103Description: 1269-79 p. digitalISSN:- 1524-4571
- Amino Acid Motifs
- Animals
- Atherosclerosis -- genetics
- Bleeding Time
- Blood Coagulation -- drug effects
- CD40 Ligand -- metabolism
- CHO Cells
- Cells, Cultured
- Chemotaxis, Leukocyte -- physiology
- Cricetinae
- Humans
- Macrophage-1 Antigen -- metabolism
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Models, Molecular
- Peptide Fragments -- pharmacology
- Peptides, Cyclic -- pharmacology
- Peritonitis -- blood
- Protein Conformation
- Protein Interaction Mapping
- Protein Structure, Tertiary
- Receptors, LDL -- deficiency
- Recombinant Fusion Proteins -- physiology
- Surface Plasmon Resonance
- Thrombosis -- etiology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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