Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in T cells and NK cells and enhances B cell function without increasing immune activation or viral replication. [electronic resource]
Producer: 20120224Description: 9229-38 p. digitalISSN:- 1873-2518
- Animals
- Antibodies, Viral -- blood
- B-Lymphocytes -- immunology
- CD4-Positive T-Lymphocytes -- immunology
- CD8-Positive T-Lymphocytes -- immunology
- Cell Proliferation
- Granzymes -- immunology
- Immunologic Memory
- Interferon-gamma -- immunology
- Interleukins -- pharmacology
- Killer Cells, Natural -- immunology
- Lymphocyte Activation
- Lysosomal-Associated Membrane Protein 1 -- metabolism
- Macaca mulatta -- immunology
- Perforin -- immunology
- Pilot Projects
- RNA, Viral -- blood
- Simian Acquired Immunodeficiency Syndrome -- drug therapy
- Simian Immunodeficiency Virus -- immunology
- Tumor Necrosis Factor Receptor Superfamily, Member 7 -- metabolism
- Viral Load
- Interleukin-21
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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