Cadmium increases HIF-1 and VEGF expression through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells. [electronic resource]
Producer: 20120606Description: 10-9 p. digitalISSN:- 1096-0929
- Animals
- Blotting, Western
- Bronchi -- blood supply
- Cadmium -- toxicity
- Cell Culture Techniques
- Cell Line
- Cell Transformation, Neoplastic -- chemically induced
- Chick Embryo
- Chorioallantoic Membrane -- blood supply
- Dose-Response Relationship, Drug
- Epithelial Cells -- drug effects
- Female
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- biosynthesis
- MAP Kinase Signaling System -- drug effects
- Mice
- Microscopy, Fluorescence
- Neoplasm Transplantation
- Neovascularization, Pathologic -- chemically induced
- Proto-Oncogene Proteins c-akt -- metabolism
- Reactive Oxygen Species -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Time Factors
- Vascular Endothelial Growth Factor A -- biosynthesis
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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