Immunization with the RTS,S/AS malaria vaccine induces IFN-γ(+)CD4 T cells that recognize only discrete regions of the circumsporozoite protein and these specificities are maintained following booster immunizations and challenge. [electronic resource]
Producer: 20120222Description: 8847-54 p. digitalISSN:- 1873-2518
- Amino Acid Sequence
- Antigen Presentation
- Antigens, Protozoan -- immunology
- CD4-Positive T-Lymphocytes -- immunology
- Cells, Cultured
- Epitopes, T-Lymphocyte -- immunology
- HLA-DR Serological Subtypes -- immunology
- HLA-DR4 Antigen -- immunology
- Humans
- Immunization, Secondary
- Interferon-gamma -- immunology
- Leukocytes, Mononuclear -- immunology
- Malaria Vaccines -- administration & dosage
- Molecular Sequence Data
- Plasmodium falciparum -- immunology
- Protozoan Proteins -- immunology
- Randomized Controlled Trials as Topic
- T-Cell Antigen Receptor Specificity
- Thrombospondin 1 -- immunology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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