Novel phosphoinositide 3-kinase/mTOR dual inhibitor, NVP-BGT226, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo. [electronic resource]
Producer: 20120325Description: 7116-26 p. digitalISSN:- 1557-3265
- Animals
- Antineoplastic Agents
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Drug Evaluation, Preclinical
- Head and Neck Neoplasms -- drug therapy
- Humans
- Imidazoles -- therapeutic use
- Male
- Mice
- Mice, Nude
- Phosphoinositide-3 Kinase Inhibitors
- Protein Kinase Inhibitors -- pharmacology
- Quinolines -- therapeutic use
- Signal Transduction -- drug effects
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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