Manganese potentiates LPS-induced heme-oxygenase 1 in microglia but not dopaminergic cells: role in controlling microglial hydrogen peroxide and inflammatory cytokine output. [electronic resource]
Producer: 20120502Description: 683-92 p. digitalISSN:- 1872-9711
- Animals
- Cell Line
- Chlorides -- toxicity
- Cytokines -- metabolism
- Dopamine -- metabolism
- Dose-Response Relationship, Drug
- Drug Synergism
- Enzyme Inhibitors -- pharmacology
- Gene Expression Regulation, Enzymologic -- drug effects
- Heme Oxygenase (Decyclizing) -- genetics
- Heme Oxygenase-1 -- antagonists & inhibitors
- Hydrogen Peroxide -- metabolism
- Inflammation Mediators -- metabolism
- Interleukin-6 -- metabolism
- Lipopolysaccharides -- pharmacology
- Maf Transcription Factors -- metabolism
- Manganese Compounds
- Membrane Proteins -- antagonists & inhibitors
- Mesencephalon -- drug effects
- Mice
- Microglia -- drug effects
- NF-E2-Related Factor 2 -- metabolism
- Neurons -- drug effects
- Nitric Oxide -- metabolism
- Nitric Oxide Synthase Type II -- antagonists & inhibitors
- Oxidative Stress -- drug effects
- RNA, Messenger -- metabolism
- Rats
- Time Factors
- Tumor Necrosis Factor-alpha -- metabolism
- Up-Regulation
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
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