1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) facilitates curcumin-induced melanoma cell apoptosis by enhancing ceramide accumulation, JNK activation, and inhibiting PI3K/AKT activation. [electronic resource]
Producer: 20120427Description: 47-54 p. digitalISSN:- 1573-4919
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Ceramides -- metabolism
- Curcumin -- pharmacology
- Drug Synergism
- Enzyme Activation
- Humans
- JNK Mitogen-Activated Protein Kinases -- metabolism
- Melanoma
- Morpholines -- pharmacology
- Phosphatidylinositol 3-Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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