Small molecular anticancer agent SKLB703 induces apoptosis in human hepatocellular carcinoma cells via the mitochondrial apoptotic pathway invitro and inhibits tumor growth invivo. [electronic resource]
Producer: 20120109Description: 44-53 p. digitalISSN:- 1872-7980
- Animals
- Antineoplastic Agents -- chemistry
- Apoptosis -- drug effects
- Blotting, Western
- Carcinoma, Hepatocellular -- drug therapy
- Caspases -- metabolism
- Dose-Response Relationship, Drug
- Enzyme Activation -- drug effects
- Female
- Hep G2 Cells
- Humans
- K562 Cells
- Liver Neoplasms, Experimental -- drug therapy
- Male
- Membrane Potential, Mitochondrial -- drug effects
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Mitochondria -- drug effects
- Mitogen-Activated Protein Kinases -- metabolism
- Phosphorylation -- drug effects
- Pyridines -- chemistry
- Rats
- Rats, Sprague-Dawley
- Thiophenes -- chemistry
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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