The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3). [electronic resource]
Producer: 20120103Description: 9845-56 p. digitalISSN:- 1520-4995
- Animals
- Binding Sites
- Cell Membrane -- metabolism
- Glutamic Acid -- chemistry
- Humans
- Kinetics
- Mice
- Models, Molecular
- Mutagenesis, Site-Directed
- NIH 3T3 Cells
- Phosphatidylinositol 4,5-Diphosphate -- metabolism
- Phosphatidylinositol Phosphates -- metabolism
- Protein Structure, Tertiary
- Proto-Oncogene Proteins c-akt -- chemistry
- Receptors, Cytoplasmic and Nuclear -- chemistry
- Recombinant Proteins -- chemistry
- Single-Cell Analysis
- Transfection
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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