Azaxanthene based selective glucocorticoid receptor modulators: design, synthesis, and pharmacological evaluation of (S)-4-(5-(1-((1,3,4-thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and its methylene homologue (BMS-791826). [electronic resource]
Producer: 20120103Description: 7318-33 p. digitalISSN:- 1520-4804
- Alkaline Phosphatase -- biosynthesis
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- chemical synthesis
- Arthritis, Experimental -- drug therapy
- Cell Line, Tumor
- Drug Partial Agonism
- Edema -- drug therapy
- Glutamate-Ammonia Ligase -- biosynthesis
- Heterocyclic Compounds, 3-Ring -- chemical synthesis
- Humans
- In Vitro Techniques
- Interleukin-1beta -- blood
- Male
- Models, Molecular
- Rats
- Rats, Inbred Lew
- Rats, Sprague-Dawley
- Receptors, Glucocorticoid -- agonists
- Response Elements
- Stereoisomerism
- Structure-Activity Relationship
- Thiadiazoles -- chemical synthesis
- Transcription Factor AP-1 -- genetics
- Transcriptional Activation
- Tumor Necrosis Factor-alpha -- blood
- Tyrosine Transaminase -- biosynthesis
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Publication Type: Journal Article
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