The combination of BH3-mimetic ABT-737 with the alkylating agent temozolomide induces strong synergistic killing of melanoma cells independent of p53. [electronic resource]
Producer: 20111222Description: e24294 p. digitalISSN:- 1932-6203
- Alkylating Agents -- pharmacology
- Animals
- Apoptosis -- drug effects
- Biomimetic Materials -- pharmacology
- Biphenyl Compounds -- pharmacology
- Cell Line, Tumor
- Dacarbazine -- analogs & derivatives
- Drug Synergism
- Female
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Melanoma -- pathology
- Mice
- Nitrophenols -- pharmacology
- Piperazines -- pharmacology
- Protein Structure, Tertiary
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Sulfonamides -- pharmacology
- Temozolomide
- Time Factors
- Tumor Suppressor Protein p53 -- metabolism
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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