Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression. [electronic resource]
Producer: 20120203Description: 106 p. digitalISSN:- 1476-4598
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- genetics
- Caspase 3 -- metabolism
- Cell Line, Tumor
- Cell Survival -- drug effects
- Chromones -- pharmacology
- Coumarins -- pharmacology
- Cyclin A -- metabolism
- Drug Resistance, Neoplasm
- Enzyme Activation
- GPI-Linked Proteins -- genetics
- Gene Expression
- Gene Knockdown Techniques
- Genes, Reporter
- Humans
- I-kappa B Kinase -- antagonists & inhibitors
- Interleukin-6 -- genetics
- Luciferases, Renilla -- biosynthesis
- Mesothelin
- Morpholines -- pharmacology
- Myeloid Cell Leukemia Sequence 1 Protein
- NF-kappa B -- antagonists & inhibitors
- Pancreatic Neoplasms
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Protein Transport
- Proto-Oncogene Proteins c-akt -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- RNA Interference
- Recombinant Proteins -- genetics
- S Phase -- drug effects
- Tumor Necrosis Factor-alpha -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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