Rho-kinase inhibition alleviates pulmonary hypertension in transgenic mice expressing a dominant-negative type II bone morphogenetic protein receptor gene. [electronic resource]
Producer: 20111222Description: L667-74 p. digitalISSN:- 1522-1504
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine -- administration & dosage
- Acute-Phase Proteins -- genetics
- Animals
- Blotting, Western
- Bone Morphogenetic Protein Receptors, Type II -- genetics
- Fluorescent Antibody Technique
- Gene Expression -- drug effects
- Hemodynamics
- Hypertension, Pulmonary -- drug therapy
- Hypertrophy, Right Ventricular -- drug therapy
- Lung -- drug effects
- Mice
- Mice, Transgenic
- Protein Kinase Inhibitors -- administration & dosage
- Protein Structure, Tertiary
- Pulmonary Artery -- drug effects
- Real-Time Polymerase Chain Reaction
- Signal Transduction -- drug effects
- Smad1 Protein -- genetics
- Smad2 Protein -- genetics
- Ventricular Dysfunction, Right -- drug therapy
- rho-Associated Kinases -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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