Stereoselective synthesis of F-ring saturated estrone-derived inhibitors of Hedgehog signaling based on cyclopamine. [electronic resource]
Producer: 20111122Description: 4786-9 p. digitalISSN:- 1523-7052
- Animals
- Cell Line
- Cell Survival -- drug effects
- Crystallography, X-Ray
- Cyclization
- Estrone -- analogs & derivatives
- Hedgehog Proteins -- antagonists & inhibitors
- Humans
- Models, Molecular
- Molecular Conformation
- Signal Transduction -- drug effects
- Stereoisomerism
- Structure-Activity Relationship
- Veratrum Alkaloids -- chemistry
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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