The antitumor effect of a novel angiogenesis inhibitor (an octahydronaphthalene derivative) targeting both VEGF receptor and NF-κB pathway. [electronic resource]
Producer: 20120730Description: 310-21 p. digitalISSN:- 1097-0215
- Angiogenesis Inhibitors -- pharmacology
- Animals
- Cell Line
- Cell Movement
- Cell Proliferation
- Extracellular Signal-Regulated MAP Kinases -- antagonists & inhibitors
- Human Umbilical Vein Endothelial Cells
- Humans
- I-kappa B Proteins -- metabolism
- Intercellular Adhesion Molecule-1 -- biosynthesis
- Interleukin-1beta -- antagonists & inhibitors
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- NF-KappaB Inhibitor alpha
- NF-kappa B -- metabolism
- Naphthols -- pharmacology
- Neovascularization, Physiologic -- drug effects
- Oncogene Protein v-akt -- metabolism
- Phosphorylation
- Pyridines -- pharmacology
- Receptors, Vascular Endothelial Growth Factor -- metabolism
- Signal Transduction -- drug effects
- Transcription Factor RelA -- antagonists & inhibitors
- Tumor Necrosis Factor-alpha -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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