Possible involvement of prolonging spinal µ-opioid receptor desensitization in the development of antihyperalgesic tolerance to µ-opioids under a neuropathic pain-like state. [electronic resource]
Producer: 20131029Description: 614-22 p. digitalISSN:- 1369-1600
- Analgesics, Opioid -- administration & dosage
- Animals
- Dose-Response Relationship, Drug
- Drug Tolerance -- physiology
- Female
- Fentanyl -- administration & dosage
- GTP-Binding Proteins -- drug effects
- Guanosine 5'-O-(3-Thiotriphosphate) -- metabolism
- Hot Temperature
- Hyperalgesia -- drug therapy
- Injections, Subcutaneous
- Ligation
- Male
- Mice
- Mice, Knockout
- Morphine -- administration & dosage
- Neuralgia -- drug therapy
- Oxycodone -- administration & dosage
- Pain Measurement -- methods
- Pain Threshold -- drug effects
- Radioligand Assay
- Receptors, Opioid, mu -- agonists
- Sciatic Nerve -- surgery
- Sodium Chloride -- administration & dosage
- Spinal Cord -- metabolism
- beta-Endorphin -- genetics
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Publication Type: Journal Article
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