Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): synthesis, structure-activity relationship, and biological activity. [electronic resource]
Producer: 20111109Description: 6254-76 p. digitalISSN:- 1520-4804
- Animals
- Antineoplastic Agents -- chemical synthesis
- Apoptosis
- Biological Availability
- Cell Line, Tumor
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Drug Screening Assays, Antitumor
- Female
- Glycine -- analogs & derivatives
- Humans
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Protein Kinase Inhibitors -- chemical synthesis
- Stereoisomerism
- Structure-Activity Relationship
- Sulfones -- chemical synthesis
- Transplantation, Heterologous
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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