Structure-function analysis of Friedreich's ataxia mutants reveals determinants of frataxin binding and activation of the Fe-S assembly complex. [electronic resource]
Producer: 20111020Description: 7265-74 p. digitalISSN:- 1520-4995
- Allosteric Regulation
- Carbon-Sulfur Lyases -- genetics
- Crystallography, X-Ray
- Enzyme Activation
- Friedreich Ataxia -- genetics
- Humans
- Iron-Binding Proteins -- chemistry
- Iron-Regulatory Proteins -- metabolism
- Iron-Sulfur Proteins -- genetics
- Kinetics
- Models, Molecular
- Mutant Proteins -- genetics
- Mutation, Missense -- genetics
- Protein Binding
- Protein Conformation
- Structure-Activity Relationship
- Sulfides -- metabolism
- Frataxin
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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