SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation. [electronic resource]
Producer: 20111024Description: 3687-99 p. digitalISSN:- 1098-5549
- Basic Helix-Loop-Helix Transcription Factors -- biosynthesis
- Boronic Acids -- pharmacology
- Bortezomib
- Cell Cycle
- Cell Cycle Proteins
- Cell Line, Tumor
- Chromatin
- Cyclopentanes -- pharmacology
- Epigenesis, Genetic
- F-Box Proteins -- metabolism
- Gene Expression Regulation
- HEK293 Cells
- HeLa Cells
- Histone Demethylases -- metabolism
- Histones -- metabolism
- Humans
- Jumonji Domain-Containing Histone Demethylases -- biosynthesis
- Mass Spectrometry
- Methylation
- Proteasome Endopeptidase Complex -- metabolism
- Protein Processing, Post-Translational
- Pyrazines -- pharmacology
- Pyrimidines -- pharmacology
- RNA Interference
- RNA, Small Interfering
- Receptors, Cytoplasmic and Nuclear -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction
- Ubiquitination
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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