cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity. [electronic resource]
Producer: 20120113Description: 1927-35 p. digitalISSN:- 1873-3913
- 1-Methyl-3-isobutylxanthine -- pharmacology
- Adaptor Proteins, Signal Transducing
- Adenylate Kinase -- metabolism
- Amino Acids -- pharmacology
- Animals
- Carrier Proteins -- metabolism
- Cell Cycle Proteins
- Cell Line
- Colforsin -- pharmacology
- Cyclic AMP -- chemistry
- Eukaryotic Initiation Factors
- Gene Deletion
- Gene Knockout Techniques
- Humans
- Insulin -- pharmacology
- Mechanistic Target of Rapamycin Complex 1
- Mice
- Monomeric GTP-Binding Proteins -- genetics
- Multiprotein Complexes
- Neuropeptides -- genetics
- Phosphodiesterase Inhibitors -- pharmacology
- Phosphoproteins -- metabolism
- Phosphorylation
- Protein Binding
- Protein Kinases -- metabolism
- Proteins -- agonists
- Ras Homolog Enriched in Brain Protein
- Recombinant Proteins -- genetics
- Ribosomal Protein S6 Kinases, 90-kDa -- metabolism
- Signal Transduction
- TOR Serine-Threonine Kinases
- Transcription Factors -- agonists
- Tuberous Sclerosis Complex 2 Protein
- Tumor Suppressor Proteins -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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