Arsenic trioxide and radiation enhance apoptotic effects in HL-60 cells through increased ROS generation and regulation of JNK and p38 MAPK signaling pathways. [electronic resource]
Producer: 20111003Description: 162-71 p. digitalISSN:- 1872-7786
- Acetylcysteine -- pharmacology
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Arsenic Trioxide
- Arsenicals -- pharmacology
- Caspase 3 -- metabolism
- Cell Cycle -- drug effects
- Cell Cycle Proteins -- metabolism
- Cell Survival -- drug effects
- Cyclins -- metabolism
- DNA Fragmentation -- drug effects
- Dose-Response Relationship, Drug
- Dose-Response Relationship, Radiation
- F-Box Proteins -- metabolism
- F-Box-WD Repeat-Containing Protein 7
- HL-60 Cells
- Humans
- JNK Mitogen-Activated Protein Kinases -- antagonists & inhibitors
- Membrane Potential, Mitochondrial -- drug effects
- Models, Biological
- Oxides -- pharmacology
- Phosphorylation -- drug effects
- Poly(ADP-ribose) Polymerases -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Reactive Oxygen Species -- metabolism
- Signal Transduction -- drug effects
- Tumor Stem Cell Assay
- Ubiquitin-Protein Ligases -- metabolism
- X-Rays
- bcl-2-Associated X Protein -- metabolism
- p38 Mitogen-Activated Protein Kinases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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