Thrombin activation of PI3K/PDK1/Akt signaling promotes cyclin D1 upregulation and RPE cell proliferation. [electronic resource]
Producer: 20111107Description: 1758-66 p. digitalISSN:- 0006-3002
- 3-Phosphoinositide-Dependent Protein Kinases
- Animals
- Cell Proliferation -- drug effects
- Cells, Cultured
- Cyclin D1 -- antagonists & inhibitors
- Models, Biological
- Oncogene Protein v-akt -- metabolism
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphorylation -- drug effects
- Protein Serine-Threonine Kinases -- metabolism
- RNA Interference
- RNA, Small Interfering -- pharmacology
- Rats
- Rats, Long-Evans
- Retinal Pigment Epithelium -- drug effects
- Signal Transduction -- drug effects
- Thrombin -- metabolism
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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