Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically-obese db/db mice. [electronic resource]
Producer: 20120116Description: 1097-104 p. digitalISSN:- 1463-1326
- AMP-Activated Protein Kinases -- metabolism
- Adipose Tissue, White -- drug effects
- Analysis of Variance
- Animals
- Blood Glucose -- drug effects
- CLOCK Proteins -- metabolism
- Cytokines
- Diet, High-Fat
- Disease Models, Animal
- Gene Expression Regulation
- Hypoglycemic Agents -- pharmacology
- Metformin -- pharmacology
- Mice
- Nicotinamide Phosphoribosyltransferase
- Obesity -- blood
- Real-Time Polymerase Chain Reaction
- Sirtuin 1 -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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