Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model. [electronic resource]
Producer: 20120109Description: 1268-79 p. digitalISSN:- 1878-5867
- Androstadienes -- chemistry
- Androstenes
- Androstenols -- chemistry
- Animals
- Antineoplastic Agents -- chemical synthesis
- Benzimidazoles -- chemistry
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Clinical Trials, Phase III as Topic
- Drug Combinations
- Estradiol -- analogs & derivatives
- Humans
- Male
- Mice
- Mice, SCID
- Norethindrone -- pharmacology
- Prostatic Neoplasms -- drug therapy
- Receptors, Androgen -- metabolism
- Steroid 17-alpha-Hydroxylase -- antagonists & inhibitors
- Structure-Activity Relationship
- Testosterone -- analogs & derivatives
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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