PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase. [electronic resource]
Producer: 20120203Description: 5353-66 p. digitalISSN:- 1557-3265
- Adenine -- analogs & derivatives
- Animals
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- genetics
- Autophagy -- drug effects
- Autophagy-Related Protein 5
- Calcium-Calmodulin-Dependent Protein Kinases -- genetics
- Carcinoma, Non-Small-Cell Lung -- drug therapy
- Caspases -- metabolism
- Cell Line, Tumor
- Death-Associated Protein Kinases
- Depsipeptides -- pharmacology
- Enzyme Activation -- drug effects
- Green Fluorescent Proteins -- genetics
- Humans
- Immunoblotting
- Lung Neoplasms -- drug therapy
- Mice
- Mice, Nude
- Microscopy, Fluorescence
- Microtubule-Associated Proteins -- genetics
- Phosphorylation -- drug effects
- Proto-Oncogene Proteins c-akt -- metabolism
- RNA Interference
- Signal Transduction -- drug effects
- TOR Serine-Threonine Kinases -- metabolism
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Retracted Publication
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