Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. [electronic resource]
Producer: 20110920Description: 845-53 p. digitalISSN:- 1546-170X
- Animals
- Disease Models, Animal
- Humans
- Janus Kinase 2 -- antagonists & inhibitors
- Mice
- Mutation -- genetics
- Polycythemia -- etiology
- Protein Multimerization -- genetics
- Pyrimidines -- pharmacology
- Sulfonamides -- pharmacology
- Suppressor of Cytokine Signaling 1 Protein
- Suppressor of Cytokine Signaling Proteins -- genetics
- Ubiquitin-Protein Ligases -- genetics
- Von Hippel-Lindau Tumor Suppressor Protein -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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