The defective nuclear lamina in Hutchinson-gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9. [electronic resource]
Producer: 20111107Description: 3378-95 p. digitalISSN:- 1098-5549
- Active Transport, Cell Nucleus
- Cell Cycle Proteins
- Guanine Nucleotide Exchange Factors
- Humans
- Nuclear Lamina -- pathology
- Nuclear Proteins
- Progeria -- metabolism
- Sumoylation
- Ubiquitin-Conjugating Enzymes -- antagonists & inhibitors
- ran GTP-Binding Protein -- metabolism
- Ubiquitin-Conjugating Enzyme UBC9
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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