Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer. [electronic resource]
Producer: 20111013Description: 2709-22 p. digitalISSN:- 1558-8238
- Acetophenones -- pharmacology
- Animals
- Antineoplastic Agents -- adverse effects
- Apoptosis -- drug effects
- Benzopyrans -- pharmacology
- Cell Line, Tumor
- Cisplatin -- adverse effects
- Enzyme Activation
- Enzyme Inhibitors -- pharmacology
- Humans
- Kidney -- drug effects
- Kidney Tubules, Proximal -- cytology
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Nude
- Mitogen-Activated Protein Kinases -- metabolism
- Neoplasm Transplantation
- Neoplasms -- drug therapy
- Protein Kinase C-delta -- antagonists & inhibitors
- Tumor Suppressor Protein p53 -- metabolism
- src-Family Kinases -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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