Could LogP be a principal determinant of biological activity in 18-crown-6 ethers? Synthesis of biologically active adamantane-substituted diaza-crowns. [electronic resource]
Producer: 20110930Description: 3444-54 p. digitalISSN:- 1768-3254
- Adamantane -- chemistry
- Algorithms
- Antineoplastic Agents -- chemical synthesis
- Bacillus subtilis -- drug effects
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cell Survival -- drug effects
- Crown Ethers -- chemical synthesis
- Drug Design
- Drug Screening Assays, Antitumor
- Escherichia coli -- drug effects
- Ethers -- chemistry
- Female
- Humans
- Hydrophobic and Hydrophilic Interactions
- Inhibitory Concentration 50
- Models, Molecular
- Neoplasms -- drug therapy
- Quantitative Structure-Activity Relationship
- Software
- Species Specificity
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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