The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity. [electronic resource]
Producer: 20120117Description: 387-408 p. digitalISSN:- 1875-8908
- Alzheimer Disease -- drug therapy
- Amyloid Precursor Protein Secretases -- antagonists & inhibitors
- Amyloid beta-Peptides -- metabolism
- Animals
- Aspartic Acid Endopeptidases -- antagonists & inhibitors
- Brain -- drug effects
- Cathepsin B -- antagonists & inhibitors
- Cysteine Proteinase Inhibitors -- pharmacology
- Disease Models, Animal
- Guinea Pigs
- Leucine -- analogs & derivatives
- Memory -- drug effects
- Mice
- Mice, Transgenic
No physical items for this record
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
There are no comments on this title.
Log in to your account to post a comment.