Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: discovery and structure-activity relationships of a series of quinoline and quinoxaline derivatives. [electronic resource]
Producer: 20110923Description: 4735-51 p. digitalISSN:- 1520-4804
- Animals
- Biological Availability
- Crystallography, X-Ray
- Humans
- In Vitro Techniques
- Liver -- blood supply
- Male
- Mice
- Models, Molecular
- Phosphatidylinositol 3-Kinases -- chemistry
- Phosphoinositide-3 Kinase Inhibitors
- Phosphorylation
- Protein Binding
- Protein Conformation
- Quinolines -- chemical synthesis
- Quinoxalines -- chemical synthesis
- Rats
- Rats, Sprague-Dawley
- Structure-Activity Relationship
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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