Humanized VB22B minibody for human Mpl stimulates human megakaryopoiesis but does not enhance platelet aggregation. [electronic resource]
Producer: 20110928Description: 829-36 p. digitalISSN:- 1873-2399
- Animals
- Antibodies -- immunology
- Benzoates -- pharmacology
- Blotting, Western
- Bone Marrow Cells -- cytology
- Cells, Cultured
- DNA -- metabolism
- Erythroid Cells -- cytology
- Flow Cytometry
- Humans
- Hydrazines -- pharmacology
- Megakaryocytes -- cytology
- Mice
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3 -- metabolism
- Myeloid Cells -- cytology
- Phosphorylation -- drug effects
- Platelet Aggregation -- drug effects
- Ploidies
- Pyrazoles -- pharmacology
- Receptors, Thrombopoietin -- agonists
- STAT3 Transcription Factor -- metabolism
- STAT5 Transcription Factor -- metabolism
- Thrombopoiesis -- drug effects
- Thrombopoietin -- pharmacology
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Publication Type: Journal Article
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