Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells. [electronic resource]
Producer: 20110912Description: 71 p. digitalISSN:- 1479-5876
- Adolescent
- Adult
- Aged
- Antigens, CD34 -- metabolism
- Apoptosis -- drug effects
- Caspase 3 -- metabolism
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Curcumin -- pharmacology
- Daunorubicin -- pharmacology
- Drug Resistance, Neoplasm -- drug effects
- Drug Synergism
- Female
- G1 Phase -- drug effects
- Gene Expression Regulation, Leukemic -- drug effects
- Humans
- Leukemia, Myeloid, Acute -- enzymology
- Male
- Membrane Potential, Mitochondrial -- drug effects
- Middle Aged
- Poly(ADP-ribose) Polymerases -- metabolism
- Protein Processing, Post-Translational -- drug effects
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- RNA, Messenger -- genetics
- RNA, Small Interfering -- metabolism
- S Phase -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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