Impact of IL-6 receptor inhibition on human memory B cells in vivo: impaired somatic hypermutation in preswitch memory B cells and modulation of mutational targeting in memory B cells. [electronic resource]
Producer: 20111118Description: 1507-10 p. digitalISSN:- 1468-2060
- Adult
- Aged
- Antibodies, Monoclonal, Humanized -- pharmacology
- Antirheumatic Agents -- pharmacology
- Arthritis, Rheumatoid -- drug therapy
- B-Lymphocyte Subsets -- drug effects
- Etanercept
- Female
- Gene Rearrangement, B-Lymphocyte -- genetics
- Humans
- Immunoglobulin G -- pharmacology
- Immunoglobulin Variable Region -- genetics
- Immunologic Memory -- genetics
- Male
- Middle Aged
- Prospective Studies
- Receptors, Interleukin-6 -- antagonists & inhibitors
- Receptors, Tumor Necrosis Factor -- therapeutic use
- Somatic Hypermutation, Immunoglobulin -- immunology
- Tumor Necrosis Factor-alpha -- antagonists & inhibitors
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Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
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