Preclinical and clinical pharmacokinetics of PF-02413873, a nonsteroidal progesterone receptor antagonist. [electronic resource]
Producer: 20111209Description: 1396-405 p. digitalISSN:- 1521-009X
- Animals
- Biotransformation
- Caco-2 Cells
- Chromatography, High Pressure Liquid
- Dogs
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Evaluation, Preclinical
- Hepatocytes -- enzymology
- Humans
- Injections, Intravenous
- Intestinal Secretions -- chemistry
- Male
- Microsomes, Liver -- enzymology
- Models, Biological
- Molecular Structure
- Predictive Value of Tests
- Prospective Studies
- Protein Binding
- Pyrazoles -- blood
- Rats
- Rats, Sprague-Dawley
- Receptors, Progesterone -- antagonists & inhibitors
- Solubility
- Species Specificity
- Sulfones -- blood
- Tandem Mass Spectrometry
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Publication Type: Journal Article; Randomized Controlled Trial
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