Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation. [electronic resource]
Producer: 20110823Description: e18146 p. digitalISSN:- 1932-6203
- Activating Transcription Factor 3 -- metabolism
- Animals
- Apoptosis -- drug effects
- Cell Line
- Endoplasmic Reticulum -- drug effects
- Enzyme Activation -- drug effects
- Glucose -- pharmacology
- Glycogen Synthase Kinase 3 -- antagonists & inhibitors
- Glycogen Synthase Kinase 3 beta
- Insulin -- metabolism
- Insulin Receptor Substrate Proteins -- metabolism
- Insulin-Secreting Cells -- cytology
- JNK Mitogen-Activated Protein Kinases -- metabolism
- Male
- Mice
- Mice, Inbred C57BL
- Palmitic Acid -- pharmacology
- Signal Transduction -- drug effects
- Sterol Regulatory Element Binding Protein 1 -- metabolism
- Stress, Physiological -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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