Nucleotide promiscuity of 3-phosphoglycerate kinase is in focus: implications for the design of better anti-HIV analogues. [electronic resource]
Producer: 20110907Description: 1863-73 p. digitalISSN:- 1742-2051
- Amino Acid Substitution
- Anti-HIV Agents -- chemistry
- Catalytic Domain
- Computer Simulation
- Creatine Kinase -- chemistry
- Drug Design
- Enzyme Assays
- Humans
- Hydrogen Bonding
- Hydrophobic and Hydrophilic Interactions
- Kinetics
- Models, Molecular
- Mutation
- Nucleoside-Diphosphate Kinase -- chemistry
- Nucleotides -- chemistry
- Phosphoglycerate Kinase -- chemistry
- Prodrugs -- chemistry
- Protein Structure, Tertiary
- Pyruvate Kinase -- chemistry
- Substrate Specificity
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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