Carba-LNA-5MeC/A/G/T modified oligos show nucleobase-specific modulation of 3'-exonuclease activity, thermodynamic stability, RNA selectivity, and RNase H elicitation: synthesis and biochemistry. [electronic resource]
Producer: 20110920Description: 4408-31 p. digitalISSN:- 1520-6904
- Base Sequence
- Cyclization
- Enzyme Stability
- Escherichia coli -- enzymology
- Exonucleases -- metabolism
- Humans
- Models, Molecular
- Molecular Conformation
- Nucleic Acid Denaturation
- Nucleic Acid Hybridization
- Oligonucleotides -- chemistry
- Oligonucleotides, Antisense -- blood
- Organophosphorus Compounds -- chemistry
- RNA -- chemistry
- Ribonuclease H -- metabolism
- Substrate Specificity
- Thermodynamics
- Transition Temperature
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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