The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors. [electronic resource]
Producer: 20110701Description: 1903-12 p. digitalISSN:- 1477-9129
- Animals
- Basic Helix-Loop-Helix Transcription Factors -- genetics
- Cell Count
- Cell Differentiation
- Cell Lineage
- Cell Proliferation
- Cyclin-Dependent Kinase 4 -- genetics
- E2F1 Transcription Factor -- genetics
- Embryonic Stem Cells -- cytology
- Female
- Gene Expression Regulation, Developmental
- Homeobox Protein Nkx-2.2
- Homeodomain Proteins -- metabolism
- Insulin-Secreting Cells -- cytology
- Male
- Mice
- Mice, Knockout
- Models, Biological
- Nerve Tissue Proteins -- genetics
- Pancreas -- cytology
- Pregnancy
- Promoter Regions, Genetic
- Signal Transduction
- Trans-Activators -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Intramural
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