Impact of the nature of the substituent at the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides on their opening activity toward ATP-sensitive potassium channels. [electronic resource]
Producer: 20110801Description: 3188-99 p. digitalISSN:- 1520-4804
- Animals
- Aorta -- drug effects
- Benzothiadiazines -- chemical synthesis
- Diazoxide -- analogs & derivatives
- Female
- Hydrogen Bonding
- Hydrogen-Ion Concentration
- In Vitro Techniques
- Insulin -- metabolism
- Insulin Secretion
- Insulin-Secreting Cells -- drug effects
- Ion Channel Gating
- KATP Channels -- physiology
- Models, Molecular
- Molecular Conformation
- Muscle Contraction -- drug effects
- Muscle Relaxation -- drug effects
- Muscle, Smooth -- drug effects
- Rats
- Rats, Wistar
- Stereoisomerism
- Structure-Activity Relationship
- Uterus -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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