An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation. [electronic resource]
Producer: 20110809Description: 5362-71 p. digitalISSN:- 1528-0020
- Amino Acid Substitution
- Animals
- Base Sequence
- Bone Marrow Transplantation
- DNA Primers -- genetics
- Embryonic Stem Cells -- cytology
- Ethylnitrosourea
- Female
- Genes, Recessive
- Hematopoiesis -- genetics
- Homozygote
- Inositol Polyphosphate 5-Phosphatases
- Interleukin-6 -- biosynthesis
- Macrophage Activation -- genetics
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Mutant Strains
- Mutagenesis
- Mutation, Missense
- Phenotype
- Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
- Phosphoric Monoester Hydrolases -- deficiency
- Protein Isoforms -- deficiency
- Signal Transduction
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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